上海交大房静远教授Cell肠道微生物与

本文转载自BioArt

Highlights

?Spcificgutmicrobstrackwithpost-chmothrapyrcurrncofcolorctalcancr

?F.nuclatumorchstratsthToll-likrcptor,microRNAs,andautophagyntworktocontrolcancrchmorsistanc

?MasuringandtargtingF.nuclatummaybusfulforpatintprognosisandmanagmnt

Summary

Gutmicrobiotaarlinkdtochronicinflammationandcarcinognsis.Chmothrapyfailuristhmajorcausofrcurrncandpoorprognosisincolorctalcancrpatints.Hr,winvstigatdthcontributionofgutmicrobiotatochmorsistancinpatintswithcolorctalcancr.WfoundthatFusobactrium(F.)nuclatumwasabundantincolorctalcancrtissusinpatintswithrcurrncpostchmothrapy,andwasassociatdwithpatintclinicopathologicalcharactrisitcs.Furthrmor,ourbioinformaticandfunctionalstudisdmonstratdthatF.nuclatumpromotdcolorctalcancrrsistanctochmothrapy.Mchanistically,F.nuclatumtargtdTLR4andMYD88innatimmunsignalingandspcificmicroRNAstoactivatthautophagypathwayandaltrcolorctalcancrchmothraputicrspons.Thus,F.nuclatumorchstratsamolcularntworkofthToll-likrcptor,microRNAs,andautophagytoclinically,biologically,andmchanisticallycontrolcolorctalcancrchmorsistanc.MasuringandtargtingF.nuclatumanditsassociatdpathwaywillyildvaluablinsightintoclinicalmanagmntandmayamlioratcolorctalcancrpatintout







































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